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pentobarbital will minimize the level or result of voriconazole by influencing hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Mysterious.Barbiturates can induce hepatic microsomal enzymes resulting in increased metabolism and diminished anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon)